Staphylococcus aureus is responsible for a high number of relapsing infections, which are often mediated by the protective nature of biofilms.Polymicrobial biofilms appear to be more tolerant to antibiotic treatment, however, the underlying mechanisms for this remain unclear.Polymicrobial biofilm and planktonic cultures formed by S.aureus and Candi
Combination of Crizotinib and Osimertinib in T790M+ EGFR-Mutant Non-Small Cell Lung Cancer with Emerging MET Amplification Post-Osimertinib Progression in a 10-Year Survivor: A Case Report
Tyrosine kinase inhibitors (TKIs) represent the standard treatment for patients with non-small kuiper belt whiskey cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agent
Epidemiological and clinical characteristics of symptomatic hereditary transthyretin amyloid polyneuropathy: a global case series
Abstract We describe 542 cases of symptomatic hereditary transthyretin amyloid polyneuropathy (ATTR-PN) identified through a review of the literature published between 2005 and 2016.Approximately 18% of the cases were from countries where ATTR-PN is traditionally considered to be endemic (i.e., Portugal, Japan, and Sweden).East Asia (Japan, China,
Transcriptome-wide Identification and Expression Analysis of Brachypodium distachyon Transposons in Response to Viral Infection
Transposable elements (TEs) are the most abundant group of genomic elements in plants that can be found in genic or intergenic regions of their host genomes.Several stimuli such as biotic or abiotic stress have roles in either activating their transcription or transposition.Here the effect of the Panicum mosaic virus (PMV) and its satellite virus (